Microencapsulation for drug delivery applications
Date: 2021/11/19 - 2021/11/19
Academic Seminar: Microencapsulation for drug delivery applications
Speaker: Xiaorong Ronald Xu, Professor, Suzhou Institute for Advanced Research, University of Science and Technology of China
Time: 10:00 - 11:30, November 19, 2021 (Beijing Time)
Location: CIMC Auditorium（Room 300）, JI Long Bin Building
Feishu: https://vc.feishu.cn/j/235090819
Abstract
Existing challenges in cancer treatment urge the development of more effective and safe drug delivery paradigms. We have explored a variety of microfabrication processes, such as multi-axial electrospray, multi-axial flow focusing, electrified flow focusing, and interface shearing, to facilitate controlled delivery, sustained release and remote activation of therapeutics. These processes are able to produce micro/nano drug carriers with nearly 100% loading efficiency, uniform size distribution, complex structures, and full protection of bioactivity. The processes are based on the formation of multilayered droplets in a high-voltage electric field or a high-speed liquid/gas flow. With these micro and nanodroplets, we have demonstrated sustained drug release, controlled drug delivery, and combinatory therapy in ex vivo, in vitro and in vivo models.
Biography
Dr. Xu is Professor of Biomedical Engineering and Professor of Precision Instrumentation at University of Science and Technology of China. He earned his PhD degree in Mechanical Engineering from Massachusetts Institute of Technology, followed by a postdoctoral research experience at Stanford University. Before joining USTC as a faculty member, he has been a faculty member at The Ohio State University for over ten years and Director of Technology Development in a medical device company for five years, leading innovative research, technology development, verification/validation, and FDA 510k applications. His teaching and research interests include medical device innovation, multimodal imaging, microencapsulation and image-guided therapy. He has carried out 6 clinical trials, published 11 patents, and authored more than 100 publications in the field. In 2010, he was profiled as one of ten best and brightest Central Ohioans in the Columbus CEO Magazine and was honored as one of two Superstars in the category of Research and Development. In 2011, he earned the TechColumbus "Inventor of the Year" Award.